SCHEMBL8728408

SCHEMBL8728408

CP(=O)(OOc1ccc(CCN)cc1)C1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.42
MAOB P27338 3/20 0.40
NUDT1 P36639 1/20 0.37
BACE1 P56817 1/20 0.37
CYP1A2 P05177 2/20 0.35
CYP2A6 P11509 1/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8730020 0.81 MEN1 (0.40) TAAR1
SCHEMBL8728401 0.74 MAOB (0.39) TAAR1MAOBNUDT1BACE1
SCHEMBL8729734 0.70 MEN1 (0.38) TAAR1MAOBNUDT1BACE1CYP1A2
SCHEMBL8729727 0.70 S1PR4 (0.43)
Decarboxylated Derivative SCHEMBL7464892 0.68 TAAR1 (0.66) TAAR1MAOBCYP1A2CYP3A4CYP2D6
SCHEMBL7214458 0.67 PARP10 (0.56) HPGD
SCHEMBL8817195 0.66 TAAR1 (0.53) TAAR1MAOB
SCHEMBL8729729 0.65 NFE2L2 (0.40) MAOB
SCHEMBL4363948 0.63 BACE1 (0.56) TAAR1NUDT1BACE1CYP1A2CYP2A6
SCHEMBL9763012 0.63 BACE1 (0.47) TAAR1NUDT1BACE1CYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726165-A HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-03-10 US disclosed
EP-0772585-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1997-05-14 EP disclosed
WO-1996004233-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed