Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431857 | 0.85 | HSD17B10 (0.41) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL15067859 | 0.81 | HSD17B10 (0.39) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL3389397 | 0.81 | HSD17B10 (0.42) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL13427886 | 0.75 | KIF11 (0.43) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL8726222 | 0.75 | KIF11 (0.44) | CYP1A2CYP2C19CYP2C9KIF11ALDH1A1 | |
| SCHEMBL5881675 | 0.75 | HSD17B10 (0.46) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL28108200 | 0.74 | ACP3 (0.46) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL5012463 | 0.74 | ACP3 (0.46) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7028514 | 0.72 | KIF11 (0.45) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL2187746 | 0.72 | HSD17B10 (0.43) | HSD17B10HPGDCYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |