Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434969 | 0.83 | CA4 (0.54) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL774134 | 0.83 | CA4 (0.54) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL136229 | 0.83 | CA4 (0.54) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL8784660 | 0.83 | CA4 (0.54) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL8726222 | 0.82 | KIF11 (0.44) | KIF11 | |
| Bromide SCHEMBL31164184 | 0.82 | CA4 (0.52) | CA4KIF11KCNH2LTA4HCA12 | |
| Hydrochloric Acid SCHEMBL30389842 | 0.82 | CA4 (0.52) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL3932304 | 0.80 | CA4 (0.50) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL10098811 | 0.80 | CA4 (0.50) | CA4KIF11KCNH2LTA4HCA12 | |
| SCHEMBL18429814 | 0.80 | CA4 (0.50) | CA4KIF11KCNH2LTA4HCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |