SCHEMBL136229

SCHEMBL136229

COc1ccc(C(OC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.54
LTA4H P09960 2/20 0.52
KIF11 P52732 9/20 0.51
KCNH2 Q12809 1/20 0.51
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
TRPA1 O75762 1/20 0.47
KMT2A Q03164 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL434969 1.00 CA4 (0.54) CA4LTA4HKIF11KCNH2CA12
SCHEMBL430047 0.91 CA1 (0.58) CA4LTA4HCA12CA1CA2
SCHEMBL774134 0.87 CA4 (0.54) CA4LTA4HKIF11KCNH2CA12
SCHEMBL8784660 0.87 CA4 (0.54) CA4LTA4HKIF11KCNH2CA12
Bromide SCHEMBL31164184 0.85 CA4 (0.52) CA4LTA4HKIF11KCNH2CA12
Hydrochloric Acid SCHEMBL30389842 0.85 CA4 (0.52) CA4LTA4HKIF11KCNH2CA12
SCHEMBL8728589 0.83 KIF11 (0.56) CA4LTA4HKIF11KCNH2CA12
SCHEMBL3932304 0.83 CA4 (0.50) CA4LTA4HKIF11KCNH2CA12
SCHEMBL21738735 0.83 KIF11 (0.56) CA4LTA4HKIF11KCNH2CA12
SCHEMBL19620174 0.83 CA4 (0.50) CA4LTA4HKIF11KCNH2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 467 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250236633-A1 SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES Roche Sequencing Solutions, Inc. (US) 2025-07-24 US claimed
EP-4499655-A1 SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES F. Hoffmann-La Roche AG (CH) 2025-02-05 EP claimed
WO-2023186842-A1 SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES F. HOFFMANN-LA ROCHE AG (CH) 2023-10-05 WO claimed
CN-113286803-A S-antigen transport inhibiting oligonucleotide polymers and methods 阿里戈斯治疗公司 2021-08-20 CN claimed
EP-3853240-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS Aligos Therapeutics, Inc. (US) 2021-07-28 EP claimed
US-20210189392-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS ALIGOS THERAPEUTICS, INC. 2021-06-24 US claimed
WO-2021119325-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS ALIGOS THERAPEUTICS, INC. (US) 2021-06-17 WO claimed
WO-2020119205-A1 RADIOACTIVE FLUORINE-LABELED LAROTRECTINIB COMPOUND AND PREPARATION METHOD THEREFOR 上海健康医学院 2020-06-18 WO claimed
US-20200147124-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS ALIGOS THERAPEUTICS, INC. 2020-05-14 US claimed
CN-109705124-A A kind of labeled with radioactive fluorine Larotrectinib compound and preparation method thereof 上海健康医学院 2019-05-03 CN claimed
US-20150099864-A1 PREPARATION OF ORGANOPHOSPHATE PEPTIDE ADDUCTS BATTELLE MEMORIAL INSTITUTE 2015-04-09 US claimed
WO-2005058246-A2 METHOD FOR PREPARING RADIOLABELED THYMIDINE MOLECULAR TECHNOLOGIES, INC. (US) 2005-06-30 WO claimed
US-20050131224-A1 Method for preparing radiolabeled thymidine CTI PET SYSTEMS, INC. 2005-06-16 US claimed
US-20030069414-A1 Urea nucleosides as therapeutic and diagnostic agents GILEAD SCIENCES, INC. 2003-04-10 US claimed
US-6414137-B1 Selective solvent extraction for the purification of protected nucleosides ALLIEDSIGNAL INC. 2002-07-02 US claimed
EP-1140957-A1 SELECTIVE SOLVENT EXTRACTION FOR THE PURIFICATION OF PROTECTED NUCLEOSIDES AlliedSignal Inc. (US) 2001-10-10 EP claimed
US-6143882-A REACTING A NUCLEOSIDE STARTING MATERIAL CONTAINING A LEAVING GROUP WITH A VINYLSTANNE OF DEFINED FORMULA AND CARBON MONOXIDE IN PRESENCE OF A PALLADIUM CATALYST TO FORM AN ENE-ONE INTERMEDIATE, REACTING WITH AN AMINE, AND ISOLATING NEXSTAR PHARMACEUTICALS, INC. (US) 2000-11-07 US claimed
WO-2000039138-A1 SELECTIVE SOLVENT EXTRACTION FOR THE PURIFICATION OF PROTECTED NUCLEOSIDES ALLIEDSIGNAL INC. (US) 2000-07-06 WO claimed
WO-1997035868-A9 UREA NUCLEOSIDES AS THERAPEUTIC AND DIAGNOSTIC AGENTS 1997-12-24 WO claimed
WO-1997035868-A1 UREA NUCLEOSIDES AS THERAPEUTIC AND DIAGNOSTIC AGENTS NEXSTAR PHARMACEUTICALS, INC. (US) 1997-10-02 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050131224-A1 Method for preparing radiolabeled thymidine TYMP, TYMS, DUT CA4 3875/4885LTA4H 1482/4885KIF11 650/4885
US-20200147124-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS RNGTT, PHAX, HAVCR2 CA4 3693/4885LTA4H 4182/4885KIF11 3088/4885
US-20030069414-A1 Urea nucleosides as therapeutic and diagnostic agents NUDT1, ADAR, DUT CA4 3774/4885LTA4H 3665/4885KIF11 3839/4885
US-20250236633-A1 SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES PARG, PPA1, PGM2 CA4 1762/4885LTA4H 3409/4885KIF11 2422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.