Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pseudoephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | RGS12 | O14924 | 1/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | THPO | P40225 | 1/20 | 0.71 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephedrine SCHEMBL8728630 | 1.00 | ADRA2C (0.71) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL8017708 | 0.90 | ADRA2C (0.71) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Pseudoephedrine SCHEMBL2081239 | 0.90 | ADRA2C (0.71) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL2081241 | 0.90 | ADRA2C (0.71) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL28507177 | 0.90 | CYP2D6 (0.76) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL3079361 | 0.89 | ADRA2C (0.69) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL1785211 | 0.89 | ADRA2C (0.69) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Pseudoephedrine SCHEMBL3079358 | 0.89 | ADRA2C (0.69) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Racephedrine SCHEMBL8733657 | 0.88 | ALDH1A1 (0.67) | ADRA2CCHRM2ADRA1ARGS12GLA | |
| Pseudoephedrine SCHEMBL8733656 | 0.88 | ALDH1A1 (0.67) | ADRA2CCHRM2ADRA1ARGS12GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145919-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | Lung Biotechnology PBC (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179427-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2015-11-26 | — | — | WO | disclosed |
| EP-0751927-A4 | SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY | CALIFORNIA INST OF TECHN (US) | 1998-07-29 | — | — | EP | disclosed |
| EP-0751927-A1 | SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1997-01-08 | — | — | EP | disclosed |
| US-5488131-A | Synthesis of compounds with predetermined chirality | CALIFORNIA INSTITUTE OF TECHNOLOGY | 1996-01-30 | — | — | US | disclosed |
| WO-1995025714-A1 | SYNTHESIS OF COMPOUNDS WITH PREDETERMINED CHIRALITY | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1995-09-28 | — | — | WO | disclosed |