Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.70 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679417 | 0.96 | PTGS2 (0.76) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8458232 | 0.89 | PTGS1 (0.74) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729555 | 0.87 | PTGS2 (0.72) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729441 | 0.87 | PTGS2 (0.91) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8733799 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8728872 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8733603 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8732029 | 0.84 | PTGS1 (0.67) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8726749 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8732399 | 0.83 | PTGS2 (0.65) | PTGS2PTGS1CXCL8AKR1B1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |