Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.70 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674683 | 0.96 | PTGS2 (0.76) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8458232 | 0.89 | PTGS1 (0.74) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729441 | 0.87 | PTGS2 (0.91) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729555 | 0.87 | PTGS2 (0.72) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8728795 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8733799 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8726594 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8733603 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8728786 | 0.84 | PTGS2 (0.60) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8726749 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1CXCL8AKR1B1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |