Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 6/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729106 | 1.00 | ADRB3 (0.49) | ADRB3HDAC8ITGB3ITGA2BACACB | |
| SCHEMBL8729117 | 0.96 | HDAC8 (0.47) | ADRB3HDAC8ITGB3ITGA2BACACB | |
| SCHEMBL8732286 | 0.87 | ACACB (0.49) | ADRB3HDAC8ITGB3ITGA2BACACB | |
| SCHEMBL8729003 | 0.87 | ACACB (0.49) | ADRB3HDAC8ITGB3ITGA2BACACB | |
| SCHEMBL8729119 | 0.87 | ACACB (0.49) | ADRB3HDAC8ITGB3ITGA2BACACB | |
| SCHEMBL8758567 | 0.83 | ACACB (0.49) | ADRB3ACACB | |
| SCHEMBL12532786 | 0.82 | BCL2 (0.59) | HDAC8ITGB3ITGA2BPTPN1BCL2 | |
| SCHEMBL19930027 | 0.82 | BCL2 (0.59) | HDAC8ITGB3ITGA2BPTPN1BCL2 | |
| SCHEMBL27460415 | 0.82 | ACACB (0.45) | HDAC8ITGB3ITGA2BACACBPTPN1 | |
| SCHEMBL3676162 | 0.80 | NPC1 (0.63) | ATMCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726165-A | HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-03-10 | — | — | US | disclosed |