Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758199 | 1.00 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR2S1PR5 | |
| SCHEMBL8636517 | 0.84 | SLC6A4 (0.50) | SLC6A4 | |
| SCHEMBL8732508 | 0.83 | S1PR1 (0.43) | S1PR1S1PR3S1PR4S1PR2S1PR5 | |
| SCHEMBL8758095 | 0.80 | ACACB (0.50) | S1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL8727063 | 0.80 | PTPN1 (0.55) | SLC6A4ADRB3 | |
| SCHEMBL8727070 | 0.80 | PTPN1 (0.55) | SLC6A4ADRB3 | |
| SCHEMBL8729688 | 0.79 | MAOB (0.42) | SLC6A4 | |
| SCHEMBL8729694 | 0.79 | MAOB (0.42) | SLC6A4 | |
| SCHEMBL8729697 | 0.79 | MAOB (0.42) | SLC6A4 | |
| SCHEMBL8727035 | 0.78 | ACACB (0.46) | ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726165-A | HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-03-10 | — | — | US | disclosed |
| EP-0772585-A1 | ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996004234-A1 | ARYLOXY ANDARYCTHIO PROPANOLAMINE DERIVATIVES USEFUL AS B3-ADRENORECEPTOR AGONISTS AND ANTAGONS OF THE B1 AND B2 ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1996-02-15 | — | — | WO | disclosed |
| WO-1996004233-A1 | ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1996-02-15 | — | — | WO | disclosed |