SCHEMBL8729694

SCHEMBL8729694

CC(N)Cc1ccc(OCP(=O)(O)CCCOCc2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.42
LTA4H P09960 4/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
SLC6A2 P23975 2/20 0.41
TAAR1 Q96RJ0 2/20 0.41
MAOA P21397 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
CYP2A6 P11509 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA1 P30542 1/20 0.41
LAP3 P28838 1/20 0.41
ENPP2 Q13822 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8729697 1.00 MAOB (0.42) MAOBLTA4HCYP2C9CYP2C19SLC6A2
SCHEMBL8729688 1.00 MAOB (0.42) MAOBLTA4HCYP2C9CYP2C19SLC6A2
SCHEMBL9056402 0.85 CYP2C19 (0.58) CYP2C9CYP2C19SLC6A2SLC6A3TDP1
SCHEMBL8732784 0.83 POLB (0.47) MAOBLTA4HCYP2C9CYP2C19TDP1
SCHEMBL8729786 0.81 SLC6A2 (0.50) CYP2C9CYP2C19SLC6A2TAAR1MAOA
SCHEMBL8726833 0.81 PPARA (0.47) ENPP2L3MBTL1
SCHEMBL8726826 0.81 PPARA (0.47) ENPP2L3MBTL1
SCHEMBL8726816 0.81 PPARA (0.47) ENPP2L3MBTL1
SCHEMBL8758199 0.79 S1PR1 (0.50) SLC6A4
SCHEMBL8729121 0.79 S1PR1 (0.50) SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726165-A HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 1998-03-10 US disclosed
EP-0772585-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1997-05-14 EP disclosed
WO-1996004233-A1 ARYLOXY AND ARYLTHIOPROPANOLAMINE DERIVATIVES USEFUL AS BETA 3-ADRENORECEPTOR AGONISTS AND ANTAGONISTS OF THE BETA 1 AND BETA 2-ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF SMITHKLINE BEECHAM PLC (GB) 1996-02-15 WO disclosed