Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.68 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.68 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolmetin SCHEMBL6439307 | 0.88 | PTGS1 (0.67) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| Water SCHEMBL9275860 | 0.83 | PTGS2 (0.72) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL7678497 | 0.83 | PTGS2 (0.72) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8729681 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8731019 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| Tolmetin SCHEMBL3150 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| Tolmetin SCHEMBL11325188 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8726561 | 0.81 | PTGS2 (0.78) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL8733603 | 0.81 | PTGS2 (0.68) | PTGS2PTGS1CXCL8AKR1B1GLO1 | |
| SCHEMBL2237360 | 0.81 | PTGS2 (0.77) | PTGS2PTGS1CXCL8AKR1B1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |