Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.72 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.72 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726489 | 0.87 | PTGS2 (0.62) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7678253 | 0.87 | PTGS2 (0.70) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8732019 | 0.87 | NR4A2 (0.59) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8726594 | 0.84 | PTGS2 (0.65) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL3150 | 0.84 | PTGS2 (1.00) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| Tolmetin SCHEMBL11325188 | 0.84 | PTGS2 (1.00) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8726561 | 0.84 | PTGS2 (0.78) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL2237360 | 0.83 | PTGS2 (0.77) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7684702 | 0.82 | PTGS2 (0.76) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7679417 | 0.82 | PTGS2 (0.76) | PTGS2CXCL8AKR1B1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |