Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986744 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL2976618 | 0.84 | GAA (0.60) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL6293793 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL2976612 | 0.84 | GAA (0.60) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL2742576 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL9449799 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL16233087 | 0.82 | SMN1; SMN2 (0.61) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4290505 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL13523692 | 0.81 | KMT2A (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL8729537 | 0.81 | POLB (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835107-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1996038143-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |