Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13523692 | 0.85 | KMT2A (0.53) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL10665226 | 0.84 | LMNA (0.49) | POLBMAPTALDH1A1MAPK1TSHR | |
| SCHEMBL13520189 | 0.83 | POLB (0.52) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL31170840 | 0.82 | ALDH1A1 (0.59) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL286994 | 0.82 | ALDH1A1 (0.59) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL8729423 | 0.81 | ALDH1A1 (0.58) | MAPTALDH1A1TSHRSMN1; SMN2LMNA | |
| SCHEMBL2710180 | 0.81 | MAPT (0.59) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL231627 | 0.81 | MAPT (0.59) | POLBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL29902848 | 0.81 | LMNA (0.52) | MAPTALDH1A1MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL29902882 | 0.81 | TSHR (0.47) | MAPTALDH1A1MAPK1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835107-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1996038143-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |