Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458233 | 0.83 | MAPT (0.46) | HDAC10MAPTSMN1; SMN2SCN1ASCN2A | |
| SCHEMBL8729772 | 0.77 | MAPT (0.40) | MAPTSMN1; SMN2SCN1ASCN2ASCN3A | |
| SCHEMBL8729572 | 0.77 | CDC25B (0.51) | HDAC10MAPTSMN1; SMN2CDC25BATM | |
| SCHEMBL8461462 | 0.77 | ATM (0.44) | HDAC10MAPTSMN1; SMN2CDC25BATM | |
| SCHEMBL10939182 | 0.75 | EGFR (0.48) | HDAC10MAPTSMN1; SMN2SCN1ASCN2A | |
| SCHEMBL8726552 | 0.72 | HDAC10 (0.64) | HDAC10MAPTSMN1; SMN2CDC25BATM | |
| SCHEMBL8726556 | 0.72 | HDAC10 (0.64) | HDAC10MAPTSMN1; SMN2CDC25BATM | |
| SCHEMBL8458232 | 0.71 | PTGS1 (0.74) | HDAC10MAPTSMN1; SMN2CDC25BATM | |
| Formic Acid Methyl Ester SCHEMBL28160973 | 0.71 | MAPT (0.58) | MAPTSMN1; SMN2CDC25BATMLMNA | |
| SCHEMBL8729395 | 0.69 | CXCL8 (0.55) | SMN1; SMN2LMNAALDH1A1CXCL8AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |