Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62555 | 0.79 | RNASEH1 (0.43) | RNASEH1 | |
| SCHEMBL63358 | 0.71 | RNASEH1 (0.43) | RNASEH1 | |
| SCHEMBL87894 | 0.70 | TSHR (0.34) | TSHR | |
| SCHEMBL14064602 | 0.70 | KDM4E (0.38) | RNASEH1KDM4E | |
| SCHEMBL87293 | 0.69 | TSHR (0.33) | TSHR | |
| SCHEMBL52517 | 0.69 | RNASEH1 (0.39) | RNASEH1 | |
| SCHEMBL52518 | 0.69 | RNASEH1 (0.39) | RNASEH1 | |
| SCHEMBL52519 | 0.69 | RNASEH1 (0.39) | RNASEH1 | |
| SCHEMBL1169995 | 0.69 | LMNA (0.35) | TSHRRNASEH1KDM4E | |
| SCHEMBL1170226 | 0.68 | LMNA (0.36) | TSHRRNASEH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | TSHR 4845/4885MAPK1 648/4885RNASEH1 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.