SCHEMBL873288

SCHEMBL873288

N#CC=C1CN(C(=O)O)C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20994916 0.84 USP30 (0.33)
SCHEMBL102170 0.79 GRM5 (0.35)
SCHEMBL18975587 0.76 ALDH1A1 (0.36)
SCHEMBL18975880 0.76 HPGD (0.47)
SCHEMBL2397660 0.75 CCR5 (0.32)
SCHEMBL23523537 0.75
SCHEMBL22609272 0.75 CYP1A2 (0.34)
SCHEMBL8509621 0.75
SCHEMBL8509625 0.75
SCHEMBL23343604 0.74 GRM5 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11685731-B2 Processes of preparing a JAK1 inhibitor INCYTE CORPORATION (US) 2023-06-27 US claimed
US-20210380563-A1 PROCESSES OF PREPARING A JAK1 INHIBITOR INCYTE CORPORATION 2021-12-09 US claimed
EP-4400172-A2 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS Incyte Holdings Corporation (US) 2024-07-17 EP disclosed
EP-4370504-A1 PROCESS AND INTERMEDIATES FOR PREPARING BARICITINIB Incyte Corporation (US) 2024-05-22 EP disclosed
US-20240150327-A1 BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION 2024-05-09 US disclosed
EP-4036088-B1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE HOLDINGS CORP (US) 2024-04-03 EP disclosed
US-11905275-B2 Bipyrazole derivatives as JAK inhibitors INCYTE CORPORATION (US) 2024-02-20 US disclosed
EP-4275756-A2 BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS Incyte Holdings Corporation (US) 2023-11-15 EP disclosed
EP-3786162-B1 BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS INCYTE HOLDINGS CORP (US) 2023-08-09 EP disclosed
US-11685731-B2 Processes of preparing a JAK1 inhibitor INCYTE CORPORATION (US) 2023-06-27 US disclosed
US-20230159501-A1 BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION 2023-05-25 US disclosed
US-20110224190-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE CORPORATION 2011-09-15 US disclosed
WO-2011112662-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE CORPORATION (US) 2011-09-15 WO disclosed
EP-2356108-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-08-17 EP disclosed
EP-2288610-A1 AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS Incyte Corporation (US) 2011-03-02 EP disclosed
WO-2010055267-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-05-20 WO disclosed
WO-2009114512-A1 AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2009-09-17 WO disclosed
WO-2009114512-A1 AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2009-09-17 WO disclosed
US-20090233903-A1 AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2009-09-17 US disclosed
US-20090233903-A1 AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2009-09-17 US disclosed