Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.71 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736459 | 0.91 | CYSLTR1 (0.71) | CYSLTR1GPBAR1ALOX5APCYSLTR2FFAR1 | |
| SCHEMBL8736043 | 0.86 | CYSLTR1 (0.60) | CYSLTR1GPBAR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL8732371 | 0.84 | CYSLTR1 (0.57) | CYSLTR1GPBAR1ALOX5APCYSLTR2FFAR1 | |
| SCHEMBL8733768 | 0.83 | CYSLTR1 (1.00) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9828521 | 0.82 | CYSLTR1 (0.58) | CYSLTR1GPBAR1ALOX5APCYSLTR2FFAR1 | |
| SCHEMBL7005048 | 0.81 | CYSLTR1 (0.66) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10545699 | 0.79 | CYSLTR1 (0.68) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL7808312 | 0.79 | CYSLTR1 (0.64) | CYSLTR1GPBAR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL8732535 | 0.79 | CYSLTR1 (1.00) | CYSLTR1GPBAR1FFAR1AKR1B1 | |
| SCHEMBL8732501 | 0.78 | CYSLTR1 (0.52) | CYSLTR1GPBAR1ALOX5APCYSLTR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |