Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.71 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733767 | 0.91 | CYSLTR1 (0.71) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8736043 | 0.89 | CYSLTR1 (0.60) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8732371 | 0.86 | CYSLTR1 (0.57) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL9828564 | 0.85 | CYSLTR1 (0.65) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8732501 | 0.84 | CYSLTR1 (0.52) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8732535 | 0.83 | CYSLTR1 (1.00) | CYSLTR1FFAR1AKR1B1GPBAR1 | |
| SCHEMBL7808312 | 0.81 | CYSLTR1 (0.64) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL10607508 | 0.81 | CYSLTR1 (0.71) | CYSLTR1FFAR1AKR1B1CYSLTR2PDE10A | |
| SCHEMBL8733768 | 0.80 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL7007566 | 0.80 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |