SCHEMBL8733779

SCHEMBL8733779

O=C(O)Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccc(Br)cc1)C2

nearest known ligand 0.70

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 15/20 0.70
MEP1B Q16820 1/20 0.47
MMP1 P03956 1/20 0.46
MMP2 P08253 1/20 0.46
MMP3 P08254 1/20 0.46
MMP7 P09237 1/20 0.46
MMP9 P14780 1/20 0.46
MMP13 P45452 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8731670 0.89 TBXA2R (0.82) TBXA2R
SCHEMBL8734661 0.88 TBXA2R (0.70) TBXA2RMEP1B
SCHEMBL5673556 0.88 TBXA2R (0.85) TBXA2R
SCHEMBL8734691 0.88 TBXA2R (0.70) TBXA2R
SCHEMBL8730048 0.88 TBXA2R (0.70) TBXA2R
SCHEMBL8730165 0.88 TBXA2R (0.70) TBXA2RMEP1B
SCHEMBL8728418 0.85 TBXA2R (0.66) TBXA2R
SCHEMBL8731718 0.85 TBXA2R (0.66) TBXA2RMMP1
SCHEMBL8731698 0.85 TBXA2R (0.66) TBXA2R
SCHEMBL8730099 0.85 TBXA2R (0.66) TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750524-A ADMINISTERING AN SULFAMIDE SUBSTITUTED INDAN DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
EP-0773019-A1 HYPERLIPEMIA REMEDY ZERIA PHARMACEUTICAL CO., LTD. (JP) 1997-05-14 EP disclosed