SCHEMBL8733880

SCHEMBL8733880

C=CC(=O)Oc1c(Cl)c(F)nc(F)c1Cl

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.31
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8733902 0.91 KMT2A (0.31) EGFR
SCHEMBL8735436 0.81 KMT2A (0.38) THRB
SCHEMBL8735405 0.81 CES2 (0.33) THRBEGFR
SCHEMBL6433548 0.81 THRB (0.33) THRBEGFR
SCHEMBL460577 0.80 THRB (0.36) THRB
SCHEMBL8735411 0.77 EGFR (0.31) EGFR
SCHEMBL8737326 0.77 EGFR (0.31) EGFR
SCHEMBL8733951 0.77 THRB (0.36) THRBEGFR
SCHEMBL29656980 0.76 THRB (0.36) THRB
SCHEMBL8733946 0.76 THRB (0.35) THRBEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824096-A2 Process for the preparation of halogenated (meth)acrylic esters and poly (meth) arcylates obtained with said (meth)acrylic esters Akzo Nobel N.V. (NL) 1998-02-18 EP disclosed