Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10751255 | 0.79 | CA1 (0.33) | CYP2C19MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17605186 | 0.77 | — | — | |
| SCHEMBL7570951 | 0.70 | KDM1A (0.50) | CYP2C19CYP3A4KMT2AKDM4EALDH1A1 | |
| SCHEMBL14463051 | 0.68 | TUBB4A (0.40) | CYP2C19MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8730062 | 0.68 | TDP1 (0.45) | CYP2C19MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL19126994 | 0.68 | KDM1A (0.36) | CYP3A4KDM4EALDH1A1 | |
| SCHEMBL6568601 | 0.68 | KDM1A (0.41) | CYP2C19CYP3A4CYP2C9KMT2AKDM4E | |
| SCHEMBL5900900 | 0.67 | CYP3A4 (0.39) | CYP2C19MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12585697 | 0.67 | CASR (0.36) | MAPTKDM4ETDP1 | |
| SCHEMBL17222065 | 0.66 | SIGMAR1 (0.37) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835107-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1996038143-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |