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SCHEMBL8734145

SCHEMBL8734145

CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CYSLTR1 Q9Y271 9/20 1.00
▸ GPBAR1 Q8TDU6 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8736452 0.85 CYSLTR1 (0.74) CYSLTR1GPBAR1
SCHEMBL8736469 0.84 CYSLTR1 (0.72) CYSLTR1GPBAR1
SCHEMBL8733757 0.84 CYSLTR1 (0.72) CYSLTR1GPBAR1
SCHEMBL8734356 0.81 CYSLTR1 (0.68) CYSLTR1GPBAR1
SCHEMBL8734127 0.80 CYSLTR1 (1.00) CYSLTR1GPBAR1
SCHEMBL8735662 0.80 CYSLTR1 (0.67) CYSLTR1GPBAR1
SCHEMBL7801642 0.79 GPBAR1 (0.81) CYSLTR1GPBAR1
SCHEMBL8734137 0.77 CYSLTR1 (0.63) CYSLTR1
SCHEMBL8736498 0.77 CYSLTR1 (0.63) CYSLTR1
SCHEMBL8736537 0.77 CYSLTR1 (0.82) CYSLTR1GPBAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 — — EP claimed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 — — WO claimed
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 — — EP disclosed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 — — WO disclosed