Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22764103 | 0.86 | TSHR (0.55) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL1004267 | 0.85 | LOXL2 (0.64) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL9865731 | 0.83 | TSHR (0.61) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL24076857 | 0.81 | TSHR (0.64) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL10569888 | 0.80 | TSHR (0.68) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL1145538 | 0.80 | LOXL2 (0.58) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL9640908 | 0.80 | TSHR (0.62) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL24076873 | 0.80 | TSHR (0.67) | LOXL2CYP2A6KCNJ1KCNH2TSHR | |
| SCHEMBL332100 | 0.79 | GFER (0.42) | CYP2A6MAOBMAOAIDO1ALDH1A1 | |
| SCHEMBL3794111 | 0.78 | TSHR (0.70) | LOXL2CYP2A6KCNJ1KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874826-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024331-A1 | NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-07-10 | — | — | WO | disclosed |
| US-5069991-A | NAPHTHOLACTAM OR ISINDOLENINE DYE | BASF AKTIENGESELLSCHAFT (DE) | 1991-12-03 | — | — | US | disclosed |