Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL28727734 | 0.96 | FFAR3 (0.46) | FFAR3TSHRALOX15CHRM2CHRM4 | |
| Glycolic Acid SCHEMBL11098490 | 0.87 | TSHR (0.44) | TSHRALOX15CHRM2CHRM4CHRM1 | |
| SCHEMBL140866 | 0.84 | — | — | |
| SCHEMBL140867 | 0.84 | — | — | |
| SCHEMBL1764859 | 0.84 | — | — | |
| Succinic Acid SCHEMBL6340677 | 0.83 | LMNA (0.34) | FFAR3TSHRALOX15CHRM2CHRM4 | |
| Succinic Acid SCHEMBL9065587 | 0.83 | LMNA (0.44) | FFAR3TSHRALOX15CHRM2CHRM4 | |
| SCHEMBL8926665 | 0.82 | TSHR (0.52) | TSHRALOX15CHRM2CHRM4CHRM1 | |
| Hydrochloric Acid SCHEMBL16086367 | 0.82 | TSHR (0.52) | TSHRALOX15CHRM2CHRM4CHRM1 | |
| Methane SCHEMBL5081883 | 0.82 | TSHR (0.52) | TSHRALOX15CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880323-A1 | MICROORGANISMS AND THEIR USE IN TREATING ANIMAL FEED AND SILAGE | BioTal Limited (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997029644-A1 | MICROORGANISMS AND THEIR USE IN TREATING ANIMAL FEED AND SILAGE | BIOTAL LTD. (GB) | 1997-08-21 | — | — | WO | disclosed |