Succinic Acid

Succinic Acid

SCHEMBL6340677

CC(=O)OC(C)C(=O)O.CCO.O=C(O)CCC(=O)O.O=CO

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.32
LMNA P02545 3/20 0.34
TSHR P16473 2/20 0.34
SLC15A2 Q16348 1/20 0.34
CYP1A2 P05177 1/20 0.34
ALOX15 P16050 1/20 0.33
HDAC3 O15379 2/20 0.32
HDAC1 Q13547 2/20 0.32
HDAC2 Q92769 2/20 0.32
HDAC8 Q9BY41 2/20 0.32
HDAC4 P56524 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM1 P11229 1/20 0.32
TBXA2R P21731 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL9065587 0.87 LMNA (0.44) LMNATSHRSLC15A2CYP1A2ALOX15
Alcohol SCHEMBL4128420 0.86 KDM6B (0.32) CYP1A2FOLH1EGLN1KDM6BKDM5C
Propionic Acid SCHEMBL8734266 0.83 FFAR3 (0.42) LMNATSHRCYP1A2ALOX15HDAC3
Pyruvate SCHEMBL7929357 0.82
Butyric Acid SCHEMBL10578465 0.82 FFAR3 (0.52) TSHRCYP1A2ALOX15HDAC3HDAC1
Propionic Acid SCHEMBL28727734 0.79 FFAR3 (0.46) LMNATSHRCYP1A2ALOX15HDAC3
Glycolic Acid SCHEMBL11098490 0.79 TSHR (0.44) LMNATSHRCYP1A2ALOX15HDAC3
Succinic Acid SCHEMBL5368117 0.78 TP53 (0.44) LMNASLC15A2CYP1A2HDAC3HDAC1
Succinic Acid SCHEMBL4128426 0.78 TP53 (0.44) LMNASLC15A2CYP1A2HDAC3HDAC1
Succinic Acid SCHEMBL5309775 0.77 LMNA (0.50) LMNATSHRSLC15A2ALOX15HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005086670-A2 PRODUCTION OF CHEMICALS FROM LIGNOCELLULOSE, BIOMASS OR SUGARS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2005-09-22 WO disclosed