Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8734374 | 0.78 | RAB9A (0.50) | PTGS2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL24106081 | 0.73 | TP53 (0.63) | PTGS2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7032874 | 0.73 | PTGS2 (0.55) | PTGS2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL31236166 | 0.73 | TP53 (0.63) | PTGS2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7032880 | 0.72 | MAPT (0.53) | RAB9ANPC1MAPTSMN1; SMN2TSHR | |
| SCHEMBL974534 | 0.71 | RAB9A (0.57) | RAB9ANPC1MAPTSMN1; SMN2TSHR | |
| SCHEMBL12239758 | 0.70 | MEN1 (0.75) | RAB9ANPC1MAPTSMN1; SMN2TP53 | |
| SCHEMBL974926 | 0.70 | MAPT (0.57) | RAB9ANPC1MAPTSMN1; SMN2TSHR | |
| SCHEMBL5553168 | 0.70 | RAB9A (0.65) | RAB9ANPC1MAPTSMN1; SMN2TSHR | |
| SCHEMBL10406349 | 0.69 | RAB9A (0.52) | RAB9ANPC1MAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050075-A1 | COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-11-12 | — | — | WO | claimed |