SCHEMBL8734677

SCHEMBL8734677

O=C(O)Cc1ccc2c(c1)CC(CNS(=O)(=O)c1ccc3ccccc3c1)C2

nearest known ligand 0.84

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 12/20 0.84
NPY5R Q15761 2/20 0.60
NPY1R P25929 1/20 0.60
HDAC3 O15379 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC2 Q92769 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
HDAC9 Q9UKV0 1/20 0.54
HDAC5 Q9UQL6 1/20 0.54
ACACB O00763 1/20 0.53
ALDH1A1 P00352 1/20 0.50
POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8731670 0.89 TBXA2R (0.82) TBXA2R
SCHEMBL8733718 0.88 TBXA2R (0.71) TBXA2RNPY5RNPY1RHDAC3HDAC4
SCHEMBL8733726 0.83 TBXA2R (0.67) TBXA2R
SCHEMBL8730165 0.83 TBXA2R (0.70) TBXA2R
SCHEMBL8734691 0.83 TBXA2R (0.70) TBXA2RALDH1A1
SCHEMBL5673556 0.83 TBXA2R (0.85) TBXA2R
SCHEMBL8733779 0.83 TBXA2R (0.70) TBXA2R
SCHEMBL8730048 0.83 TBXA2R (0.70) TBXA2R
SCHEMBL8734661 0.83 TBXA2R (0.70) TBXA2R
SCHEMBL8734662 0.83 TBXA2R (0.83) TBXA2RNPY5RNPY1RALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750524-A ADMINISTERING AN SULFAMIDE SUBSTITUTED INDAN DERIVATIVE ZERIA PHARMACEUTICAL CO., LTD. (JP) 1998-05-12 US disclosed
EP-0773019-A1 HYPERLIPEMIA REMEDY ZERIA PHARMACEUTICAL CO., LTD. (JP) 1997-05-14 EP disclosed
EP-0589037-B1 INDIAN DERIVATIVE AND THROMBOXANE ANTAGONIST CONTAINING THE SAME ZERIA PHARM CO LTD (JP) 1996-05-29 EP disclosed
US-5409956-A A sulfonylaminoalkylindan carboxylic acid or ester for treating thrombosis, vasospasm or asthma ZERIA PHARMACEUTICAL CO., LTD. (JP) 1995-04-25 US disclosed
EP-0589037-A1 INDIAN DERIVATIVE AND THROMBOXANE ANTAGONIST CONTAINING THE SAME ZERIA PHARMACEUTICAL CO., LTD. (JP) 1994-03-30 EP disclosed