SCHEMBL8734893

SCHEMBL8734893

[CH2]c1ccccc1N(C)C.[Ti]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.43
GAA P10253 4/20 0.43
ALDH1A1 P00352 4/20 0.43
TSHR P16473 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
TP53 P04637 1/20 0.43
KDM4E B2RXH2 2/20 0.42
CHEK1 O14757 1/20 0.41
NEK2 P51955 1/20 0.41
LIMK1 P53667 1/20 0.41
DYRK1A Q13627 1/20 0.41
CLK4 Q9HAZ1 1/20 0.41
HTR6 P50406 2/20 0.38
LMNA P02545 2/20 0.38
NSD2 O96028 1/20 0.38
EGFR P00533 1/20 0.38
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
EP300 Q09472 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL169416 0.97 MAPT (0.44) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL27974730 0.95 MAPT (0.43) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL29055174 0.95 MAPT (0.43) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL7946689 0.95 MAPT (0.43) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL2491630 0.78 MAPT (0.42) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL28875374 0.77 MAPT (0.37) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL65263 0.76 MAPT (0.55) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL815705 0.75 MAPT (0.44) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL816506 0.75 MAPT (0.44) MAPTGAAALDH1A1TSHRSMN1; SMN2
SCHEMBL2092236 0.73 EGFR (0.38) ALDH1A1SMN1; SMN2LMNAEGFRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103402636-B Manufacture the method for modified metal cyclopentadienyl catalyst, the catalyst made and application thereof 格雷斯公司 2016-12-14 CN disclosed
CN-103402636-A Process of making modified metallocene catalyst, catalyst produced and use thereof GRACE W R & CO 2013-11-20 CN disclosed
CN-1205235-C Functionalized catalyst supports and supported catalyst system DOW CHEMICAL CO (US) 2005-06-08 CN disclosed
CN-1152062-C Olefin solution polymerization �Ϻ���ͨ��ѧ 2004-06-02 CN disclosed
CN-1373144-A Monoolefin/polyene copolymer, its preparation process, composition contg. said copolymer and products produced therefrom DOW CHEMICAL CO (US) 2002-10-09 CN disclosed
CN-1084342-C Mono-olefin/multi-olefin interpolymers, process for making the same, compositions containing the same, and articles made therefrom DOW CHEMICAL CO (US) 2002-05-08 CN disclosed
CN-1317018-A Functionalized catalyst supports and supported catalyst systems DOW CHEMICAL CO (US) 2001-10-10 CN disclosed
CN-1219178-A Olefin solution polymerization DOW CHEMICAL CO (US) 1999-06-09 CN disclosed
CN-1203606-A Mono-olefin/multi-olefin interpolymers, process for making the same, compositions containing the same, and articles made therefrom DOW CHEMICAL CO (US) 1998-12-30 CN disclosed
EP-0632819-B1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES DOW CHEMICAL CO (US) 1998-09-02 EP disclosed
US-5532394-A CONTAINING TITANIUM, DIVALENT MOIETY, LINKING GROUP, MONOVALENT ANIONIC STABILIZING GROUP THE DOW CHEMICAL COMPANY (US) 1996-07-02 US disclosed
EP-0632819-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1995-01-11 EP disclosed
WO-1993019104-A1 ADDITION POLYMERIZATION CATALYSTS COMPRISING REDUCED OXIDATION STATE METAL COMPLEXES THE DOW CHEMICAL COMPANY (US) 1993-09-30 WO disclosed