Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10499129 | 0.88 | KDM4E (0.50) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL1498169 | 0.88 | KDM4E (0.50) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL27271173 | 0.88 | KDM4E (0.50) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL8688366 | 0.86 | KDM4E (0.48) | PRSS1PRSS2PRSS3F2BCAT2 | |
| Sulfuric Acid SCHEMBL11905560 | 0.86 | KDM4E (0.48) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL11499388 | 0.86 | KDM4E (0.48) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL8517044 | 0.86 | KDM4E (0.48) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL6536729 | 0.79 | CES1 (0.45) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| Acrylamide SCHEMBL29263992 | 0.78 | KDM4E (0.41) | PRSS1PRSS2PRSS3F2BCAT2 | |
| SCHEMBL18921204 | 0.77 | ALDH1A1 (0.48) | PRSS1PRSS2PRSS3F2BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831823-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-10-21 | — | — | EP | disclosed |
| EP-0831823-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040135-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |