Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 6/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934553 | 0.84 | MAPT (0.43) | DRD2GAAKDM4EALDH1A1NPSR1 | |
| SCHEMBL20539283 | 0.84 | DRD2 (0.44) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL7023211 | 0.84 | DRD2 (0.42) | DRD2KDM4EALDH1A1DRD3DRD4 | |
| Hydrogen Sulfide SCHEMBL27838727 | 0.83 | MAPT (0.42) | DRD2GAAKDM4EALDH1A1NPSR1 | |
| SCHEMBL16926997 | 0.82 | DRD2 (0.41) | DRD2KDM4ENPSR1DRD3DRD4 | |
| Iodide SCHEMBL8733616 | 0.82 | DRD2 (0.41) | DRD2KDM4EALDH1A1DRD3DRD4 | |
| Iodide SCHEMBL8735171 | 0.81 | SLC22A12 (0.49) | DRD2KDM4EALDH1A1NPSR1DRD3 | |
| SCHEMBL18015659 | 0.81 | DRD2 (0.43) | DRD2KDM4EALDH1A1DRD3DRD4 | |
| SCHEMBL30665126 | 0.81 | DRD2 (0.42) | DRD2GAAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2984151 | 0.81 | DRD2 (0.42) | DRD2GAAALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697387-B1 | Improved method for the preparation of iodonium salts | DOW CORNING (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5426222-A | Mixing iodoarene dicarboxylate, solvent, adding acid to form homogeneous reaction mixture, reacting with benzene or substituted benzene, stripping solvent | DOW CORNING CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |