SCHEMBL873540

SCHEMBL873540

CCCCc1ccc(OCCN(CC)CC)cc1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
LTA4H P09960 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2C9 P11712 1/20 0.62
CYP2C19 P33261 1/20 0.62
HTT P42858 1/20 0.62
BIRC5 O15392 1/20 0.56
KCNH2 Q12809 1/20 0.56
ESR1 P03372 1/20 0.56
ESR2 Q92731 1/20 0.56
EBP Q15125 1/20 0.55
SIGMAR1 Q99720 1/20 0.55
HRH3 Q9Y5N1 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10898516 0.90 CYP1A2 (0.66) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL873480 0.86 CYP1A2 (0.57) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL16933991 0.86 LMNA (0.62) CYP1A2LTA4HCYP2D6HRH3
SCHEMBL16572095 0.85 MEN1 (0.56)
SCHEMBL18837482 0.85 HRH3 (0.58) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL874146 0.85 HRH3 (0.74) LTA4HKCNH2ESR1ESR2HRH3
SCHEMBL9706125 0.84 EBP (0.72) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL3973648 0.83 CYP1A2 (0.62) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL25505298 0.83 KCNH2 (0.70) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19
SCHEMBL8432273 0.82 CYP1A2 (0.70) CYP1A2LTA4HCYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2619184-A2 DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME The Regents of the University of Michigan (US) 2013-07-31 EP disclosed
WO-2012040527-A2 DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-03-29 WO disclosed