Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.39 |
| ▸ | BTK | Q06187 | 12/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735184 | 0.79 | BTK (0.48) | BTK | |
| SCHEMBL8736917 | 0.77 | BRD4 (0.35) | BRD4BTKAURKATTKAURKB | |
| SCHEMBL8736925 | 0.72 | BTK (0.65) | BTK | |
| SCHEMBL3655731 | 0.67 | BTK (0.54) | BRD4BTK | |
| SCHEMBL27333258 | 0.66 | ALDH1A1 (0.56) | BRD4AURKB | |
| SCHEMBL8735172 | 0.65 | MAP2K1 (0.35) | — | |
| SCHEMBL3751483 | 0.65 | BTK (0.40) | BRD4BTK | |
| SCHEMBL5130622 | 0.65 | BTK (0.46) | BRD4BTK | |
| SCHEMBL1322005 | 0.63 | BRD4 (0.44) | BRD4BTKAURKATTKAURKB | |
| SCHEMBL1038341 | 0.62 | BTK (0.70) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822457-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140194413-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ROCHE PALO ALTO LLC (US) | 2014-07-10 | — | — | US | disclosed |
| US-20120129845-A1 | Inhibitors of Bruton's Tyrosine Kinase | DEWDNEY NOLAN JAMES (HK) | 2012-05-24 | — | — | US | disclosed |
| US-8124604-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2012-02-28 | — | — | US | disclosed |
| US-20110105479-A1 | Inhibitors of Bruton's Tyrosine Kinase | DEWDNEY NOLAN JAMES | 2011-05-05 | — | — | US | disclosed |
| US-7902194-B2 | Inhibitors of bruton's tyrosine kinase | Roche Palo Alto (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090318448-A1 | 7-Dimethylamino-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3H-quinazolin-4-one; asthma ; inhibit Btk | ROCHE PALO ALTO LLC | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105479-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | BRD4 398/4885BTK 1/4885AURKA 965/4885 |
| US-20090318448-A1 | 7-Dimethylamino-3-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3H-quinazolin-4-one; asthma ; inhibit Btk | BTK, LCK, SYK | BRD4 65/4885BTK 1/4885AURKA 1121/4885 |
| US-20120129845-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | BRD4 398/4885BTK 1/4885AURKA 965/4885 |
| US-20140194413-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | BRD4 398/4885BTK 1/4885AURKA 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.