Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 6/20 | 0.37 |
| ▸ | RARG | P13631 | 6/20 | 0.37 |
| ▸ | RARA | P10276 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298330 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL5176543 | 0.90 | ALDH1A1 (0.41) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL29645042 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL3505332 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL18741108 | 0.85 | RARB (0.40) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL19561440 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL7794100 | 0.80 | ALDH1A1 (0.37) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL6017377 | 0.78 | RXRA (0.39) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL18741109 | 0.77 | RARB (0.40) | ALDH1A1MEN1GAAMAPTHPGD | |
| SCHEMBL30298339 | 0.77 | RARB (0.40) | ALDH1A1MEN1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699178-B1 | TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN INC (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5602135-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ARTHEROSCLEROSIS,IMMUNOLOGY, WOUND HEALING AGENT, VISION DEFECTS, SUNSCREEN AGENTS | ALLERGAN | 1997-02-11 | — | — | US | disclosed |