Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 6/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736423 | 0.89 | STAT3 (0.43) | KDM4EALDH1A1 | |
| SCHEMBL8736415 | 0.86 | CHRM1 (0.53) | CHRM1TOP1MAPT | |
| SCHEMBL8735563 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1 | |
| SCHEMBL8733989 | 0.79 | KDM4E (0.47) | KDM4ECHRM1TOP1TOP2ATOP2B | |
| SCHEMBL8733567 | 0.77 | KDM4E (0.48) | KDM4ECHRM1TOP1ALDH1A1 | |
| SCHEMBL8731834 | 0.74 | KDM4E (0.43) | KDM4ETOP1TOP2ATOP2BALDH1A1 | |
| SCHEMBL8735858 | 0.73 | KDM4E (0.40) | KDM4ETOP1TOP2ATOP2BALDH1A1 | |
| SCHEMBL8736445 | 0.72 | KDM4E (0.50) | KDM4ETOP1ALDH1A1 | |
| SCHEMBL21787284 | 0.71 | TOP1 (0.68) | CHRM1TOP1 | |
| SCHEMBL7009985 | 0.71 | CHRM1 (0.61) | KDM4ECHRM1TOP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878194-A1 | REMEDIES OR PREVENTIVES FOR AIDS | SANKYO COMPANY LIMITED (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5688791-A | COMPOUNDS FOR TREATMENNT OF VIRAL DISEASES SUCH AS AIDS | UBE INDUSTRIES, LTD. (JP) | 1997-11-18 | — | — | US | disclosed |
| US-5519016-A | Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent | UBE INDUSTRIES, LTD. (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0572259-A1 | Aminoquinolone derivatives as anti-HIV agents | UBE INDUSTRIES, LTD. (JP) | 1993-12-01 | — | — | EP | disclosed |