SCHEMBL873632

SCHEMBL873632

CCOC(=O)C1CCN(c2ncnc(Cl)c2F)CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.58
KMT2A Q03164 4/20 0.58
POLB P06746 3/20 0.58
RAB9A P51151 1/20 0.58
MAPK1 P28482 2/20 0.57
ALDH1A1 P00352 7/20 0.56
KDM4E B2RXH2 7/20 0.56
SMN1; SMN2 Q16637 4/20 0.56
TSHR P16473 3/20 0.56
HPGD P15428 3/20 0.56
HSD17B10 Q99714 3/20 0.56
ALOX12 P18054 1/20 0.56
MEN1 O00255 3/20 0.54
TP53 P04637 2/20 0.51
GAA P10253 2/20 0.50
USP2 O75604 1/20 0.49
KLK7 P49862 1/20 0.49
GPR119 Q8TDV5 1/20 0.49
CYP2C19 P33261 1/20 0.49
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30547494 0.86 KDM4E (0.51) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL25559759 0.86 KDM4E (0.51) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL25768665 0.86 MAPT (0.58) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL1673823 0.82 GPR119 (0.66) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL19156615 0.82 MAPT (0.40) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL25195814 0.80 KMT2A (0.58) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL31383398 0.80 KMT2A (0.58) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL25559978 0.79 MAPT (0.52) MAPTKMT2APOLBRAB9AMAPK1
SCHEMBL19156448 0.79 KDM4E (0.47) MAPTKMT2APOLBALDH1A1KDM4E
SCHEMBL17549245 0.79 KDM4E (0.45) MAPTKMT2AALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4430037-B1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORP (US) 2025-10-29 EP disclosed
EP-4573090-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION (US) 2025-06-25 EP disclosed
US-20250122186-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORP (US) 2025-04-17 US disclosed
CN-119731170-A Isoxazolidines as RIPK1 inhibitors and their use 建新公司 2025-03-28 CN disclosed
EP-4430037-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION (US) 2024-09-18 EP disclosed
CN-118510775-A Isoxazolidines as RIPK1 inhibitors and their use 建新公司 2024-08-16 CN disclosed
US-20240109882-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORP (US) 2024-04-04 US disclosed
WO-2024040155-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION (US) 2024-02-22 WO disclosed
US-11897876-B2 Isoxazolidines as RIPK1 inhibitors and use thereof GENZYME CORPORATION (US) 2024-02-13 US disclosed
US-20230203027-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION 2023-06-29 US disclosed
US-20230203027-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF GENZYME CORPORATION 2023-06-29 US disclosed
WO-2023083847-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF SANOFI (FR) 2023-05-19 WO disclosed
WO-2023083847-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF SANOFI (FR) 2023-05-19 WO disclosed
US-20210340133-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. 2021-11-04 US disclosed
US-10894787-B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2021-01-19 US disclosed
EP-3323818-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2018-05-23 EP disclosed
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US disclosed
EP-2619198-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2013-07-31 EP disclosed
WO-2012040279-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2012-03-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230203027-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF RIPK1, RIPK2, RIPK3 MAPT 4157/4885KMT2A 3551/4885POLB 2771/4885
US-20240109882-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF RIPK1, RIPK2, RIPK3 MAPT 4157/4885KMT2A 3551/4885POLB 2771/4885
US-11897876-B2 Isoxazolidines as RIPK1 inhibitors and use thereof RIPK1, RIPK2, RIPK3 MAPT 4157/4885KMT2A 3551/4885POLB 2771/4885
US-20210340133-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, SLC5A2 MAPT 1297/4885KMT2A 706/4885POLB 4686/4885
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, DPP4 MAPT 1392/4885KMT2A 636/4885POLB 4663/4885
US-20250122186-A1 ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF RIPK1, RIPK2, RIPK3 MAPT 4157/4885KMT2A 3551/4885POLB 2771/4885
US-10894787-B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto GPR119, GLP1R, DPP9 MAPT 1583/4885KMT2A 915/4885POLB 4702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.