Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | RARA | P10276 | 2/20 | 0.34 |
| ▸ | RARB | P10826 | 2/20 | 0.34 |
| ▸ | RARG | P13631 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746394 | 0.80 | CYP26A1 (0.57) | CYP26A1CYP26B1NQO2SNCAKMT2A | |
| SCHEMBL10439232 | 0.66 | MMP2 (0.48) | NQO2SNCADEGS1KMT2AMEN1 | |
| SCHEMBL6340122 | 0.66 | BACE1 (0.37) | CYP26A1CYP26B1SNCADEGS1KMT2A | |
| SCHEMBL7746406 | 0.65 | CYP26A1 (0.53) | CYP26A1CYP26B1KMT2AMEN1CYP3A4 | |
| SCHEMBL6873454 | 0.64 | CYP26A1 (0.54) | CYP26A1CYP26B1NQO2SNCADEGS1 | |
| SCHEMBL7928437 | 0.64 | RARB (0.55) | CYP26A1CYP26B1CYP3A4RARARARB | |
| SCHEMBL7746076 | 0.64 | CYP26A1 (0.48) | CYP26A1CYP26B1CYP3A4RARARARB | |
| SCHEMBL7752015 | 0.63 | CYP26A1 (0.51) | CYP26A1CYP26B1KMT2AMEN1CYP3A4 | |
| SCHEMBL10439244 | 0.63 | DEGS1 (0.69) | NQO2SNCADEGS1KMT2AMEN1 | |
| SCHEMBL10439472 | 0.63 | DEGS1 (0.46) | NQO2SNCADEGS1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832057-A1 | DIAROMATIC PROPYNYL OR DIENYL COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-04-01 | — | — | EP | claimed |
| WO-1997033856-A1 | DIAROMATIC PROPYNYL OR DIENYL COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | claimed |