Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382383 | 0.85 | SMN1; SMN2 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3415969 | 0.76 | MEN1 (0.44) | HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3383321 | 0.73 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC11 | |
| SCHEMBL8736688 | 0.73 | ALDH1A1 (0.36) | FFAR1TSHR | |
| SCHEMBL8735900 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNANPC1RAB9ATDP1 | |
| SCHEMBL1687805 | 0.73 | ALDH1A1 (0.36) | TSHR | |
| SCHEMBL8085465 | 0.71 | LMNA (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3381675 | 0.70 | MAPT (0.50) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3384260 | 0.70 | CYP2C19 (0.35) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| 5-Phenylvaleric Acid SCHEMBL15263366 | 0.69 | MAPT (0.92) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5795877-A | Inhibitors of NAALADase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | claimed |
| US-5795877-A | Inhibitors of NAALADase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |