Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598516 | 0.85 | APLNR (0.49) | APLNRKMT2AMAPTPLCG1SMN1; SMN2 | |
| SCHEMBL1259871 | 0.77 | APLNR (0.52) | APLNRKMT2APLCG1SMN1; SMN2HTT | |
| SCHEMBL294920 | 0.77 | APLNR (0.52) | APLNRKMT2APLCG1MEN1HTT | |
| SCHEMBL2717301 | 0.77 | KMT2A (0.57) | APLNRKMT2APLCG1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL28180679 | 0.76 | APLNR (0.50) | APLNRKMT2APLCG1MEN1HTT | |
| SCHEMBL294919 | 0.75 | APLNR (0.53) | APLNRKMT2APLCG1SMN1; SMN2HTT | |
| SCHEMBL3237396 | 0.75 | PKM (0.56) | APLNRKMT2APLCG1SMN1; SMN2MEN1 | |
| SCHEMBL30496480 | 0.75 | PKM (0.56) | APLNRKMT2APLCG1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL27633192 | 0.75 | KMT2A (0.55) | APLNRKMT2APLCG1SMN1; SMN2MEN1 | |
| SCHEMBL2377998 | 0.75 | APLNR (0.58) | APLNRKMT2APLCG1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455382-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-05-23 | — | — | EP | disclosed |