Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8739266 | 0.93 | EZH2 (0.62) | EZH2L3MBTL1NPC1RAB9AKMT2A | |
| SCHEMBL8739014 | 0.89 | EZH2 (0.67) | EZH2L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL8738307 | 0.89 | EZH2 (0.67) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738621 | 0.88 | EZH2 (0.66) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738126 | 0.88 | EZH2 (0.66) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738209 | 0.87 | EZH2 (0.65) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739045 | 0.87 | EZH2 (0.64) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739018 | 0.86 | EZH2 (0.68) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738211 | 0.86 | EZH2 (0.68) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8738206 | 0.86 | EZH2 (0.73) | EZH2L3MBTL1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |