Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 6/20 | 0.62 |
| ▸ | F10 | P00742 | 7/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738150 | 0.93 | EZH2 (0.64) | EZH2L3MBTL1KMT2AABL1NPC1 | |
| SCHEMBL8738307 | 0.90 | EZH2 (0.67) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8738621 | 0.87 | EZH2 (0.66) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8738126 | 0.87 | EZH2 (0.66) | EZH2F10L3MBTL1KMT2A | |
| SCHEMBL8738209 | 0.87 | EZH2 (0.65) | EZH2L3MBTL1KMT2APKM | |
| SCHEMBL8739045 | 0.86 | EZH2 (0.64) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8738211 | 0.85 | EZH2 (0.68) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8739018 | 0.85 | EZH2 (0.68) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8738206 | 0.85 | EZH2 (0.73) | EZH2L3MBTL1KMT2A | |
| SCHEMBL8738204 | 0.85 | EZH2 (0.69) | EZH2L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |