Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.68 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16689220 | 0.88 | LMNA (0.69) | HRH3KEAP1NFE2L2LTA4HLMNA | |
| SCHEMBL874125 | 0.85 | CYP1A2 (0.56) | HRH3LTA4HLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2549152 | 0.85 | HRH3 (0.64) | HRH3KEAP1NFE2L2LTA4HLMNA | |
| SCHEMBL7150669 | 0.84 | HRH3 (0.62) | HRH3KEAP1NFE2L2LTA4HESR1 | |
| SCHEMBL10937896 | 0.82 | LMNA (0.57) | LMNAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL14951699 | 0.82 | L3MBTL1 (0.76) | LMNAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL26455103 | 0.82 | LMNA (0.66) | LMNAL3MBTL1HDAC6ALDH1A1MEN1 | |
| Ethylene SCHEMBL10898156 | 0.81 | HRH3 (0.58) | HRH3KEAP1NFE2L2LTA4HESR1 | |
| SCHEMBL24457814 | 0.81 | LMNA (0.55) | LTA4HLMNAL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL1809723 | 0.81 | L3MBTL1 (0.69) | LMNAL3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |