Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120964 | 0.89 | EZH2 (1.00) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL17067333 | 0.88 | L3MBTL1 (0.74) | EZH2L3MBTL1MEN1KMT2APKM | |
| SCHEMBL310763 | 0.86 | KMT2A (0.82) | EZH2L3MBTL1MEN1KMT2APKM | |
| SCHEMBL8738591 | 0.85 | EZH2 (1.00) | EZH2L3MBTL1MEN1KMT2AGLA | |
| SCHEMBL8738134 | 0.85 | EZH2 (0.80) | EZH2L3MBTL1MEN1KMT2APKM | |
| SCHEMBL8738562 | 0.85 | EZH2 (0.80) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL2908330 | 0.84 | EZH2 (0.89) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739024 | 0.84 | EZH2 (0.69) | EZH2L3MBTL1MEN1KMT2A | |
| SCHEMBL8738109 | 0.84 | EZH2 (0.74) | EZH2L3MBTL1MEN1KMT2AATM | |
| SCHEMBL8739283 | 0.84 | EZH2 (0.76) | EZH2MEN1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |