Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | EZH2 | Q15910 | 9/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738166 | 0.84 | MEN1 (0.60) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8739451 | 0.75 | MEN1 (0.55) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8738999 | 0.74 | KMT2A (0.59) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8739672 | 0.74 | MEN1 (0.61) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8738120 | 0.73 | MEN1 (0.60) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8738652 | 0.73 | MEN1 (0.57) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8739686 | 0.73 | KMT2A (0.57) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL6120920 | 0.73 | MEN1 (0.77) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8739211 | 0.73 | MEN1 (0.57) | MEN1KMT2ACYP2C9EZH2GLA | |
| SCHEMBL8739727 | 0.72 | EZH2 (0.56) | MEN1KMT2ACYP2C9EZH2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |