Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738166 | 0.86 | MEN1 (0.60) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL169747 | 0.76 | EZH2 (0.80) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL2908330 | 0.74 | EZH2 (0.89) | EZH2MEN1KMT2AGLAL3MBTL1 | |
| SCHEMBL8738588 | 0.72 | EZH2 (1.00) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL6119822 | 0.72 | EZH2 (0.80) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL27636094 | 0.72 | EZH2 (0.70) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL8738574 | 0.72 | MEN1 (0.56) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL8738186 | 0.71 | EZH2 (0.67) | EZH2CYP2C9 | |
| SCHEMBL14679120 | 0.71 | POLB (0.73) | EZH2CYP2C9MEN1KMT2AGLA | |
| SCHEMBL6121185 | 0.71 | EZH2 (0.72) | EZH2CYP2C9MEN1KMT2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |