Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 9/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169747 | 0.91 | EZH2 (0.80) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL14679120 | 0.85 | POLB (0.73) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL6121185 | 0.85 | EZH2 (0.72) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL24904611 | 0.84 | EZH2 (0.49) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL9002597 | 0.84 | EZH2 (0.70) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL13683724 | 0.84 | EZH2 (0.70) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL6120701 | 0.84 | EZH2 (0.70) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL27636094 | 0.84 | EZH2 (0.70) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL17067286 | 0.84 | MEN1 (0.71) | EZH2GLAPOLBKMT2AMEN1 | |
| SCHEMBL2908330 | 0.83 | EZH2 (0.89) | EZH2GLAPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |