Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 13/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120862 | 0.89 | EZH2 (0.74) | EZH2KMT2AHSD17B10 | |
| SCHEMBL8738976 | 0.88 | EZH2 (0.72) | EZH2KMT2ATSHRHSD17B10 | |
| SCHEMBL8739254 | 0.88 | EZH2 (0.72) | EZH2KMT2ATSHR | |
| SCHEMBL8739235 | 0.87 | EZH2 (0.68) | EZH2KMT2AHSD17B10 | |
| SCHEMBL6120964 | 0.83 | EZH2 (1.00) | EZH2KMT2ATSHR | |
| SCHEMBL8738546 | 0.82 | EZH2 (0.80) | EZH2KMT2A | |
| SCHEMBL8738562 | 0.82 | EZH2 (0.80) | EZH2KMT2A | |
| SCHEMBL8739010 | 0.81 | EZH2 (0.70) | EZH2KMT2ATSHR | |
| SCHEMBL3295907 | 0.80 | KMT2A (0.69) | EZH2KMT2AHSD17B10 | |
| SCHEMBL8739466 | 0.79 | EZH2 (0.73) | EZH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |