Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738699 | 0.87 | EZH2 (0.71) | EZH2KMT2AHSD17B10 | |
| SCHEMBL6120862 | 0.87 | EZH2 (0.74) | EZH2KMT2AMEN1HSD17B10 | |
| SCHEMBL8739254 | 0.86 | EZH2 (0.72) | EZH2KMT2AMEN1 | |
| SCHEMBL8738976 | 0.86 | EZH2 (0.72) | EZH2KMT2AHSD17B10L3MBTL1 | |
| SCHEMBL8739010 | 0.84 | EZH2 (0.70) | EZH2KMT2A | |
| SCHEMBL6120964 | 0.81 | EZH2 (1.00) | EZH2KMT2AMEN1ATML3MBTL1 | |
| SCHEMBL8738546 | 0.81 | EZH2 (0.80) | EZH2KMT2AMEN1PKMATM | |
| SCHEMBL8738134 | 0.80 | EZH2 (0.80) | EZH2KMT2AMEN1PKMATM | |
| SCHEMBL17067305 | 0.79 | ATM (0.62) | EZH2KMT2AMEN1PKMHSD17B10 | |
| SCHEMBL8738144 | 0.79 | EZH2 (1.00) | EZH2KMT2AMEN1PKMATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |