Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738975 | 0.91 | MEN1 (0.61) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738156 | 0.85 | EZH2 (0.76) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8739225 | 0.82 | EZH2 (0.78) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL169747 | 0.81 | EZH2 (0.80) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL6120173 | 0.78 | EZH2 (0.77) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL310763 | 0.78 | KMT2A (0.82) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8739251 | 0.78 | EZH2 (0.76) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL6121204 | 0.77 | EZH2 (0.74) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL2908330 | 0.77 | EZH2 (0.89) | EZH2MEN1KMT2AL3MBTL1GLA | |
| SCHEMBL8738545 | 0.76 | EZH2 (0.79) | EZH2MEN1KMT2AL3MBTL1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068589-A2 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |