Sugi Predict

Sugi Predict / Compounds / SCHEMBL8739130

SCHEMBL8739130

SCHEMBL8739130

Nc1ccc(-n2ccc(C(F)(F)F)n2)c(-n2ccc(C(F)(F)F)n2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.46
▸ NPC1 O15118 3/20 0.39
▸ MAPT P10636 3/20 0.39
▸ PDE3B Q13370 1/20 0.39
▸ PDE3A Q14432 1/20 0.39
▸ RAB9A P51151 2/20 0.37
▸ MBOAT4 Q96T53 1/20 0.35
▸ IDH1 O75874 4/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ PAX8 Q06710 1/20 0.35
▸ IDH2 P48735 1/20 0.35
▸ POLB P06746 2/20 0.35
▸ GLA P06280 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ GRM2 Q14416 1/20 0.34
▸ NTRK1 P04629 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2627214 0.91 PRMT6 (0.46) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL2161462 0.87 PDE3B (0.47) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL2633108 0.87 PRMT6 (0.43) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL1354818 0.77 NPC1 (0.52) PRMT6NPC1MAPTRAB9AIDH1
SCHEMBL21071706 0.76 PRMT6 (0.36) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL8739541 0.74 POLB (0.43) NPC1MAPTPDE3BPDE3ARAB9A
SCHEMBL15400993 0.73 PRMT6 (0.46) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL9082652 0.73 PRMT6 (0.49) PRMT6NPC1MAPTPDE3BPDE3A
SCHEMBL30492741 0.72 PRMT6 (0.44) PRMT6NPC1MAPTRAB9AMBOAT4
SCHEMBL29541208 0.71 PRMT6 (0.38) PRMT6NPC1MAPTPDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 — — US disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 — — US disclosed
US-10000482-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2018-06-19 — — US disclosed
US-9802937-B2 Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-10-31 — — US disclosed
US-9637491-B2 Pyrazolo[4,3-D]pyrimidines as kinase inhibitors ORIGENIS GMBH (DE) 2017-05-02 — — US disclosed
US-9499535-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2016-11-22 — — US disclosed
EP-2699572-B1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2016-08-10 — — EP disclosed
US-20150297595-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. 2015-10-22 — — US disclosed
EP-2699579-B1 PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-10-07 — — EP disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20120329785-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 — — US disclosed
US-20120329780-A1 Novel kinase inhibitors ORIGENIS GMBH (DE) 2012-12-27 — — US disclosed
US-8318755-B2 Inhibitors of SYK and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-11-27 — — US disclosed
US-20120130073-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2012-05-24 — — US disclosed
US-20120101275-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2012-04-26 — — US disclosed
US-8063058-B2 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-22 — — US disclosed
US-8063058-B2 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-22 — — US disclosed
US-20100048567-A1 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS INC. (US) 2010-02-25 — — US disclosed
US-20100048567-A1 Inhibitors of syk and JAK protein kinases PORTOLA PHARMACEUTICALS INC. (US) 2010-02-25 — — US disclosed
WO-2009136995-A2 INHIBITORS OF SYK PROTEIN KINASE PORTOLA PHARMACEUTICALS, INC. (US) 2009-11-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150297595-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES SYK, BTK, JAK1 PRMT6 2053/4885NPC1 3576/4885MAPT 985/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK PRMT6 1221/4885NPC1 4727/4885MAPT 501/4885
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK PRMT6 945/4885NPC1 4398/4885MAPT 470/4885
US-20120130073-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES SYK, BTK, JAK1 PRMT6 2053/4885NPC1 3576/4885MAPT 985/4885
US-20120101275-A1 INHIBITORS OF SYK AND JAK PROTEIN KINASES SYK, BTK, JAK1 PRMT6 2053/4885NPC1 3576/4885MAPT 985/4885
US-20120329780-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK PRMT6 945/4885NPC1 4398/4885MAPT 470/4885
US-20120329785-A1 Novel kinase inhibitors LRRK2, MYLK2, MYLK3 PRMT6 797/4885NPC1 4130/4885MAPT 634/4885
US-20100048567-A1 Inhibitors of syk and JAK protein kinases SYK, BTK, JAK1 PRMT6 2053/4885NPC1 3576/4885MAPT 985/4885
US-10000482-B2 Kinase inhibitors LRRK2, MYLK2, MYLK PRMT6 964/4885NPC1 4434/4885MAPT 438/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK PRMT6 964/4885NPC1 4434/4885MAPT 438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.